Tuesday, May 04, 2021

Genomic Surveillance - SARS-CoV-2 Virus

The advent of technology has enabled the possibility of using genome sequences to understand and combat the SARS-CoV-2 pandemic that started in 2019. Genome sequencing is particularly helpful in outbreak analysis and intervention, identifying variants and their pathological basis of spreading and infection, and a host of other possible understanding and paving way for interventions. It has been more than a year since the pandemic affected several countries now. They have been coping up and investing in infrastructure development and attending to immediate needs to help people. But simultaneously, countries have also set up genomic surveillance because that, along with epidemiological surveillance is important for treatment strategies and to curb the spread. India too has set up its genomic surveillance consortium, INSACOG (http://dbtindia.gov.in/insacog) - in the late 2020s, which is helping scientists study the spread and infection of the disease. However, as of now, the number of genome sequences in GISAID (https://www.gisaid.org) doesn't seem to commensurate with the number of reported cases, particularly in India, and more specifically in Tamilnadu. See the figures below (data collected from GISAID as of 9 am on 03 May 2021). 



With the establishment of INSACOG and a good sampling strategy, I think the situation would improve in the coming days. I also hope that the government/research agencies will include more sequencing partners, improve clinic-academia partnership etc to improve genomic surveillance. 

Going forward, I think India should set up a robust genomic surveillance network to tackle any future endemic/epidemic/pandemic. A lot of thoughts and funds need to put into this in addition to investing in building up the overall public health infrastructure. 

Friday, January 01, 2021

Learnings 2020

 I think the important learnings over the last year for me was: 

1. One needs opportunity to showcase talent. 

2. People in positions of responsibility should create the opportunity for others intentionally. 

3. People in positions of responsibility should also create a "community" of interest groups. It is in being together we flourish!